Prediction of protein domain boundaries from inverse covariances
نویسندگان
چکیده
منابع مشابه
Prediction of protein domain boundaries from inverse covariances
It has been known even since relatively few structures had been solved that longer protein chains often contain multiple domains, which may fold separately and play the role of reusable functional modules found in many contexts. In many structural biology tasks, in particular structure prediction, it is of great use to be able to identify domains within the structure and analyze these regions s...
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Successful prediction of protein domain boundaries provides valuable information not only for the computational structure prediction of multidomain proteins but also for the experimental structure determination. Since protein sequences of multiple domains may contain much information regarding evolutionary processes such as gene-exon shuffling, this information can be detected by analyzing the ...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics
سال: 2012
ISSN: 0887-3585,1097-0134
DOI: 10.1002/prot.24181